24 - AIIMS november 2008 pathology mcqs

53.MHC IS LOCCATED ON WHICH CHROMOSOME?

A. 10
B. 6
C.X
D. 13

answer is B . 6 th chromosome .

54.BRCA 1 IS LOCATED ON CHROMOSOME?

A. 13
B. 11
C. 17
D. 22

the answer is C . 17 th chromosome .

55. GENE FOR FOLATE CARRIER PROTEIN IS LOCATED ON CHROMOSOME?

A. 5
B. X
C. 21
D. 9

the answer is C. 21 st chromosome .

56.ALL ARE TRUE ABOUT THROMBOTIC THROMBOCYTOPENIC PURPURA EXCEPT?
]
A. MICROANGIOPATHIC HEMOLYTIC ANEMIA
B. THROMBOCYTOPENIA
C. NORMAL COMPLEMENT LEVEL
D. THROMBOSIS

57.ESSENTIAL FOR TUMOUR METASTASIS IS?

A. ANGIOGENESIS
B.TUMOROGENESIS
C. APOPTOSIS
D. INHIBITION OF TYROSINE KINASE ACTIVITY

58. COMMON COMPLEMENT COMPONENT FOR BOTH PATHWAYS IS?

A. C3
B. C5
C. C1q
D. C8

59.ENZME RESPONSIBLE FOR RESPIRATORY BURST IS?

A. OXIDASE
B. DEHYDROGENASE
C. PEROXIDASE
D.CATALASE



60.MOST POTENT STIMULATOR OF NAÏVE T CELL IS?

A. MATURE DENDRITIC CELL
B. FOLLICULAR DENDRITIC CELL
C. MACROPHAGE
D. B CELL

answer is B . dendritic cell. its a repeat from the old AIIMS papers.

61.NITROBLUE TETRAZOLIUM TEST IS USED FOR?

A. PHAGOCYTES
B. COMPLEMENT
C. T CELL
D. B CELL

62.HYPERSENSITIVITY VASCULITIS IS SEEN IN?

A. POST CAPILLARY VENULES
B. ARTERIOLES
C. VEINS
D. CAPILLARIES

to view all the 200 mcqs of AIIMS november 2008 click here

23 - immunoglobulins mcqs and faqs

1. Ig that crosses the placenta ?

Answer: Ig G .

2. Ig present in milk ?

Answer: Ig G and Ig A

3. Ig in seromucinous glands ?

Answer: Ig G and Ig A

4. Ig in primary immune response ?

Answer: Ig M

5. Ig in secondary immune response ?

Answer: Ig G

6. Ig with maximum molecular weight ?

Answer: Ig M

7. Ig with maximum sedimentation rate ?

Answer: Ig M

8. Ig with minimum sedimentation coefficient ?

Answer: Ig G

9. Blood group antibodies belong to which type of immunoglobulins ?

answer: Ig M

10. Rheumatoid factor belongs to which type of immunoglobulins ?

answer: Ig M ( antibody against Fc fragment of Ig G )

11. Immunoglobulin that is heat labile ?

answer: Ig E .

12. Immunoglobulin mediating the prausnitz kustner reaction ?

Answer: Ig E

13. Ig appearing first in life ?

Answer: Ig M

14. homocytotropism is seen in which Ig ?

answer: Ig E .

15. Ig with maximum serum concentration ?

Answer: Ig G

16. Ig with minimum serum concentration ?

Answer: Ig E

17. Ig with longest half life ?

Answer: Ig G

18. Ig with shortest half life ?

Answer: Ig E

19. Ig with maximum synthesis per day ?

Answer: Ig A

20. Ig with minimum synthesis per day ?

Answer: Ig E

21. Ig responsible for hypersensitivity pneumonitis ?

Answer: Ig G

22. binary exposure to an antigen results in sudden increase in ?

answer: Ig G

23. Ig to fix complements via classical pathway ?

Answer: Ig G1 and Ig M

24. Ig to fix complements via alternate pathway ?

Answer: Ig A , Ig D , Ig G4

22 - morphological changes in myocardial infarction

Evolution of Morphologic Changes in Myocardial Infarction

Time	Gross Features	Light Microscopic Findings
0-½ hr	None	None
½-4hr	None	Usually none; variable waviness of fibers at border
4-12hr	Occasionally dark mottling	Beginning coagulation necrosis; edema; hemorrhage
12-24hr	Dark mottling	Ongoing coagulation necrosis; pyknosis of nuclei; myocyte hypereosinophilia; marginal contraction band necrosis; beginning neutrophilic infiltrate
1-3 days	Mottling with yellow-tan infarct center	Coagulation necrosis, with loss of nuclei and striations; interstitial infiltrate of neutrophils
3-7 days	Hyperemic border; central yellow-tan softening	Beginning disintegration of dead myofibers, with dying neutrophils; early phagocytosis of dead cells by macrophages at infarct border
7-10 days	Maximally yellow-tan and soft, with depressed red-tan margins	Well-developed phagocytosis of dead cells; early formation of fibrovascular granulation tissue at margins
10-14 days	Red-gray depressed infarct borders	Well-established granulation tissue with new blood vessels and collagen deposition
2-8wk	Gray-white scar, progressive from border toward core of infarct	Increased collagen deposition, with decreased cellularity
More Than 2mon- ths	Scarring complete	Dense collagenous scar

21 - echinocyte ( burr cell )

Definition:

Red cell membrane abnormality characterized by short, blunt projections (spicules) of relatively uniform length and evenly distributed over the red cell surface. In early stage of development the red cell maintains a discoid shape (echinocyte I), but may progress to a spherical shape (echinocyte IV, spheroechinocyte).

Pathobiology:

Due to an expansion of the outer leaflet of the lipid bilayer, and the abnormality is reversible.

Differential Diagnosis:

• Artifact- blood smear improperly prepared, usually due to a delay in the preparation of the blood smear from EDTA-anticoagulated blood sample.
• Aging of red cells in vitro, e.g. transfused blood- due to ATP depletion and lysolecithin formation.
• Renal insufficiency
• Impact hemolysis
• Liver disease
• Hypophosphatemia and hypomagnesemia (malnutrition)
• Pyruvate kinase deficiency
• Severe burns

20 - dacrocyte

Dacryocyte is a pear-shaped or tear-shaped red blood cell that is usually seen in a broad spectrum of infiltrative disorders that disrupt the bone marrow architecture and also in extramedullary hematopoiesis.hence it is called TEAR DROP CELL .

The abnormality is thought to be due to membrane damage to the red cell during maturation in a crowded bone marrow environment, damage at the time of exit from the bone marrow and subsequent circulation through the spleen.

These cells are usually seen in disorders such as myelofibrosis, metastatic tumor in the bone marrow, extramedullary hematopoiesis, dyserythropoiesis, megaloblastic anemias, thalassemia especially in thalassemia major, acute leukemias, and in multiple myelomas.

19 - kaposi sarcoma

Kaposi's sarcoma typically produces one or more reddish purple nodules on the skin, as seen here grossly.

18 - normal heart

This is the external appearance of a normal heart.The epicardial surface is smooth and glistening.The amount of epicardial fat is usual.The left anterior descending coronary artery extends down from the aortic root to the apex.

17 - pathology mcqs - 71 to 80

71) Urease producing all except

a. H. pylori

b. Salmonella

c. Klebsilla

d. proteus

Answer : b) Salmonella

Reference: Microbiology 7^th Edition Pages 290

72) Vibrio Cholera usually is transported using

a. VR Medium

b. BSA Medium

c. GTTA Medium

d. None of the above

Answer : a) VR medium

Reference: Microbiology 7^th Edition Page 306

73) An example of Double Stranded RNA virus is

a. Reo

b. Rhabdovirus

c. Polio Virus

d. None of the above

Answer : reo

Reference: Microbiology 7^th Edition Page 448

74) All of the following are non Enveloped DNA virus except

a. Herpes virus

b. Adeno virus

c. Parvo virus

d. Papavovirus

Answer : a) Herpes virus

Reference: Microbiology 7^th Edition Page 446

75) About Ancylostoma all are true except

a. Also called as hook worm

b. Causes Anemia

c. All infections are symptomatic

d. Related with ground itch

Answer : All infections are symptomatic

Reference: Harrison 15^th Edition Chapter 220

76) Lyme’s disease is caused by

a. borrelia burgdoferi

b. COxilla burnetti

c. Leptospirosis

d. None of the above

Answer : a) Borrelia Burgdoferi

Reference: Microbiology 7^th Edition Page 389

77) Graft from genetically identical member of same species is

a. Allograft

b. Autograft

c. Isograft

d. Xenograft

Answer : c) Isograft

Reference: Microbiology 7^th Edition Page 177

78) A man has inhaled actinomycoses vulgaris (Thermoactinomycosis). He will develop

a. Farmer’s lung

b. Byssionosis

c. Baggassosis

d. Anthracosis

Answer : a) Farmer’s Lung

Reference: Harrison 15^th Edition Chapter 250

79) Mc Conkey medium is an example of

a. Transport medium

b. Differential Medium

c. Selective medium

d. Simple medium

Answer : B) Differential Medium

Reference: Microbiology 7^th Edition Page 37

80) Painless diarrhea occurs in

a. Viral diseases

b. Campylobacter diarrhoea

c. Shigella

d. Cholera

Answer : d) Cholera

Reference: Harrison 15^th Edition Chapter 159

16 - pathology mcqs - 61 to 70

61) Reactivity of false positive VDRL in Acute Malaria is

a. 10 to 20 %

b. 10 to 30 %

c. 50 %

d. 100 %

Answer : ??

62) Calabar Swelling is seen in

a. loa loa

b. Manso

c. Wucherchia bancrofti

d. Brugui malayi

Answer : a) Loa loa

Reference: Harrison 15^th Edition Chapter 221

63) Bacteria in air first demonstrated by

a. Louis Pasteur

b. Lister

c. Ronald Ross

d. Koch’s

Answer : a) Louis Pasteur

Reference: Microbiology 7^th Edition Page 2

64) All are contributions of Louis Pasteur except

a. Sterilisation

b. Vaccine for Rabies

c. Vaccine for anthrax

d. Vaccine for Tuberculosis

Answer : d) Vaccine for Tuberculosis

Reference: Microbiology 7^th Edition Page 2

65) Sereny test is positive in

a. Enteropathogenic E.Coli

b. Entero invasive E.Coli

c. enterotoxic E.Coli

d. verotoxic E.Coli

Answer : b) Enetero Invasive E.Coli

Reference: Microbiology 7^th Edition Page 279

66) The main clinically significatnt Toxin produced by C.diphteria is

a. Exotoxin

b. Endotoxin

c. Both

d. None

Answer : a) Exotoxin

Reference: Microbiology 7^th Edition Page 233

67) Inverted fir tree appearance in swab culture is seen with

a. Bacillus Anthracis

b. Brucella

c. Bordetella

d. None

Answer : a) Bacillus Anthracis

Reference: Microbiology 7^th Edition Page 243

68) Fastidious organism are grown by

a. prolonging incubation time

b. and performing special subcultures

c. both

d. none

Answer : c) both

Reference: Harrison 15^th Edition Chap 126

69) Virus causing Hemorrhagic conjunctivtitis virus is

a. Arbovirus

b. Entero Virus 70

c. Rabies virus

d. Herpes Virus

Answer : b) Enterovirus 70

Reference: Harrison 15^th Edition Chapter 193

70) Most Common organism causing nosocomial infection is hospital acquired pneumonia

a. Pseudomonas

b. Staph aureus

c. Streptococcus

d. Both A and B

Answer : d) both a and B

Reference: Harrison 15^th Edition Chap 255

15 - pathology mcqs - 51 to 60

51) Hepatitis B is a

a. Single Stranded DNA Virus

b. Double Stranded DNA Virus

c. Single Stranded RNA Virus

d. Double Stranded RNA Virus

Answer : (B) Double Stranded DNA Virus

Refernce: Ananthanarayanan 7^th Edition Page 550

Ä All DNA Viruses are Double Stranded except Parvovirus which is a Single stranded DNA Virus

Ä All RNA Viruses are Single Stranded except Reovirus which is a Double stranded DNA Virus

52) Hepatitis C Virus is transmitted by

a. Blood products

b. Food

c. Air

d. None of the above

Answer (a) Blood Products

Reference: Ananthanarayanan 7^th Edition Page 557

53) Shape of Rabies Virus

a. Ball Shaped

b. Egg Shaped

c. Bullet Shaped

d. Boat shaped

Answer (c) Bullet shaped

Reference: Ananthanarayanan 7^th Edition Page 535

54) The drug that is not commonly given for Pneumococcal Pneumonia is

a. Penicillin

b. Gentamycin

c. Erythromycin

d. Cefotaxime

Answer : (b) Gentamycin

Reference: Harrison 16^th Edition Page 810

55) Prozone Phenomenon is seen in cases of

a. Antibody Excess

b. Antigen Excess

c. Both

d. None

Answer (A) Antibody Excess

Reference: Ananthanarayanan 7^th Edition Page 95

Note : Antigen Excess is Post Zone

56) Allergy and Anaphylaxis are due to

a. IgE

b. IgA

c. IgG

d. Ig M

Answer (a) IgE

Reference: Ananthanarayanan 7^th Edition Page 90

57) Paul Bannel Test uses

a. Sheep RBC

b. Foul RBC

c. Guinea Pig RBC

d. Human RBC

Answer (a) Sheep RBC

Reference: Ananthanarayanan 7^th Edition Page 99, 484

58) Protein Structure is found using

a. Southern Blot

b. Northen Blot

c. Western blot

d. Any of the above

Answer : C) Western blot

Reference: Ananthanarayanan 7^th Edition Page 592

59) Nagler reaction is due to

a. Cl.Welchi

b. Pseudomonas

c. Streptococcus

d. Mycobacteria

Answer (a) Cl.welchi

Reference: Ananthanarayanan 7^th Edition Page 250

60) Gamma carboxylation of Glutamic acid residues require

a. Ca⁺⁺

b. Na⁺

c. K⁺

d. Cl^-

Answer (a) Ca⁺⁺ ions

Reference: KDTripathi 5^th Edition Page 564