25 - abnormal hemoglobins with altered synthesis and function mcqs

1q: what is the hemoglobin that results when glutamate in the 6th position of beta chain is replaced by valine ?

a. hemoglobin S or sickle cell hemoglobin
b. hemoglobin C
c. hemoglobin E
d. hemoblogin Yakima

answer a . sickle cell hemoglobin also called as hemoglobin S . this is mostly seen in African population and is characterized by anemia and ischemic infarcts .

2q: what is the hemoglobin that results when glutamate in the 6th position of the beta chain is replaced by lysine ?

a. hemoglobin S or sickle cell hemoglobin
b. hemoglobin C
c. hemoglobin E
d. hemoblogin Yakima

answer b . hemoglobin C . this is mostly seen in African population .hemoglobin C is characterized by mild anemia and interacts with HbS ./option>

3q: what is the hemoglobin that results when glutamate in the 26th position of the beta chain is replaced by lysine ?

a. hemoglobin S or sickle cell hemoglobin
b. hemoglobin C
c. hemoglobin E
d. hemoblogin Yakima

answer c . hemoglobin E . HbE is characterized by microcytic anemia, splenomegaly and thalassemic phenotype. This is mostly seen in southeast asian population .

4q: what is the hemoglobin that results when valine in the 98th position of the beta chain is replaced by methionine ?

a. Hb koln
b. Hb Yakima
c. Hb Kansas
d. Hb M. iwata

answer a . Hb koln . this type of hemoglobin is not specific to one kind of population and occurs sporadically. It is characterized by hemolytic anemia, Heinz bodies when splenectomized .

5q: what is the hemoglobin that results when aspartate in the 99th position of the beta chain is replaced by histidine ?

a. Hb koln
b. Hb Yakima
c. Hb Kansas
d. Hb M.iwata

answer. Hb Yakima . it occurs sporadically and is characterized by polycythemia .

6q: what is the hemoglobin that results when asparagine in the 102nd position of the beta chain is replaced by lysine ?

a. Hb koln
b. Hb Kansas
c. Hb M.iwata
d. Hb Yakima

answer b . Hb kansas . this also occurs sporadically and is characterized by mild anemia

7q: what is the hemoglobin that results when histidine in the 87th position of the alpha chain is replaced by tyrosine ?

a. Hb koln
b. Hb Kansas
c. Hb Yakima
d. Hb M.iwata

answerd. Hb M.iwata . this also occurs sporadically and is characterized by methemoglobinemia .