25 - abnormal hemoglobins with altered synthesis and function mcqs

1q: what is the hemoglobin that results when glutamate in the 6th position of beta chain is replaced by valine ?

a. hemoglobin S or sickle cell hemoglobin
b. hemoglobin C
c. hemoglobin E
d. hemoblogin Yakima

answer a . sickle cell hemoglobin also called as hemoglobin S . this is mostly seen in African population and is characterized by anemia and ischemic infarcts .

2q: what is the hemoglobin that results when glutamate in the 6th position of the beta chain is replaced by lysine ?

a. hemoglobin S or sickle cell hemoglobin
b. hemoglobin C
c. hemoglobin E
d. hemoblogin Yakima

answer b . hemoglobin C . this is mostly seen in African population .hemoglobin C is characterized by mild anemia and interacts with HbS ./option>

3q: what is the hemoglobin that results when glutamate in the 26th position of the beta chain is replaced by lysine ?

a. hemoglobin S or sickle cell hemoglobin
b. hemoglobin C
c. hemoglobin E
d. hemoblogin Yakima

answer c . hemoglobin E . HbE is characterized by microcytic anemia, splenomegaly and thalassemic phenotype. This is mostly seen in southeast asian population .

4q: what is the hemoglobin that results when valine in the 98th position of the beta chain is replaced by methionine ?

a. Hb koln
b. Hb Yakima
c. Hb Kansas
d. Hb M. iwata

answer a . Hb koln . this type of hemoglobin is not specific to one kind of population and occurs sporadically. It is characterized by hemolytic anemia, Heinz bodies when splenectomized .

5q: what is the hemoglobin that results when aspartate in the 99th position of the beta chain is replaced by histidine ?

a. Hb koln
b. Hb Yakima
c. Hb Kansas
d. Hb M.iwata

answer. Hb Yakima . it occurs sporadically and is characterized by polycythemia .

6q: what is the hemoglobin that results when asparagine in the 102nd position of the beta chain is replaced by lysine ?

a. Hb koln
b. Hb Kansas
c. Hb M.iwata
d. Hb Yakima

answer b . Hb kansas . this also occurs sporadically and is characterized by mild anemia

7q: what is the hemoglobin that results when histidine in the 87th position of the alpha chain is replaced by tyrosine ?

a. Hb koln
b. Hb Kansas
c. Hb Yakima
d. Hb M.iwata

answerd. Hb M.iwata . this also occurs sporadically and is characterized by methemoglobinemia .

24 - AIIMS november 2008 pathology mcqs

53.MHC IS LOCCATED ON WHICH CHROMOSOME?

A. 10
B. 6
C.X
D. 13

answer is B . 6 th chromosome .

54.BRCA 1 IS LOCATED ON CHROMOSOME?

A. 13
B. 11
C. 17
D. 22

the answer is C . 17 th chromosome .

55. GENE FOR FOLATE CARRIER PROTEIN IS LOCATED ON CHROMOSOME?

A. 5
B. X
C. 21
D. 9

the answer is C. 21 st chromosome .

56.ALL ARE TRUE ABOUT THROMBOTIC THROMBOCYTOPENIC PURPURA EXCEPT?
]
A. MICROANGIOPATHIC HEMOLYTIC ANEMIA
B. THROMBOCYTOPENIA
C. NORMAL COMPLEMENT LEVEL
D. THROMBOSIS

57.ESSENTIAL FOR TUMOUR METASTASIS IS?

A. ANGIOGENESIS
B.TUMOROGENESIS
C. APOPTOSIS
D. INHIBITION OF TYROSINE KINASE ACTIVITY

58. COMMON COMPLEMENT COMPONENT FOR BOTH PATHWAYS IS?

A. C3
B. C5
C. C1q
D. C8

59.ENZME RESPONSIBLE FOR RESPIRATORY BURST IS?

A. OXIDASE
B. DEHYDROGENASE
C. PEROXIDASE
D.CATALASE



60.MOST POTENT STIMULATOR OF NAÏVE T CELL IS?

A. MATURE DENDRITIC CELL
B. FOLLICULAR DENDRITIC CELL
C. MACROPHAGE
D. B CELL

answer is B . dendritic cell. its a repeat from the old AIIMS papers.

61.NITROBLUE TETRAZOLIUM TEST IS USED FOR?

A. PHAGOCYTES
B. COMPLEMENT
C. T CELL
D. B CELL

62.HYPERSENSITIVITY VASCULITIS IS SEEN IN?

A. POST CAPILLARY VENULES
B. ARTERIOLES
C. VEINS
D. CAPILLARIES

to view all the 200 mcqs of AIIMS november 2008 click here